Non-specific effects of vaccines: plausible and potentially important, but implications uncertain

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Non-specific effects of childhood vaccines

Non-specific effects of vaccines or “off target effects” as they are sometimes called can be defined as effects of a vaccine beyond their intended target pathogen or disease. These effects can be beneficial as well as harmful. The published evidence on non-specific effects of childhood vaccines remain confusing, so the linked systematic reviews by Higgins and colleagues (doi:10.1136/bmj.i5170) ...

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The non-specific effects of vaccines in low income countries.

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Do measles vaccines have non-specific effects on mortality?

Letters Do measles vaccines have non-specific effects on mortality? Editor – Cooper et al. (1) reviewed the non-specific effects on mortality of childhood vaccines. Although there are numerous studies detailing mortality following measles vaccination (MV) (2), only two studies cited in their article (3, 4) satisfied the authors' methodological criteria. The Zaire (3) and Bangladesh (4) studies ...

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Do childhood vaccines have non-specific effects on mortality?

A recent article by Kristensen et al. suggested that measles vaccine and bacille Calmette-Gu rin (BCG) vaccine might reduce mortality beyond what is expected simply from protection against measles and tuberculosis. Previous reviews of the potential effects of childhood vaccines on mortality have not considered methodological features of reviewed studies. Methodological considerations play an es...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 2017

ISSN: 0003-9888,1468-2044

DOI: 10.1136/archdischild-2015-310282